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Biotinyl-ProTx-II（生物素-原毒素-II）
簡(jiǎn)要描述：Smartox Biotechnology是*一家專(zhuān)門(mén)生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號(hào)：12PTB002- 廠商性質(zhì)：代理商
- 更新時(shí)間：2024-10-29
- 訪 問(wèn) 量：1485
產(chǎn)品介紹
Biotinyl-ProTx-II（生物素-原毒素 II）
ProTx-II (Protoxin-II) is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula).ProTx-II inhibits both tetrodotoxin-sensitive and tetrodotoxin-resistant channels. ProTx-II inhibits activation by shifting the voltage-dependence of c hannel activation to more positive potentials. ProTx-II potently inhibits all sodium channel subtypes tested (Nav1.2/SCN2A, Nav1.5/SCN5A, Nav1.7/SCN9A, and Nav1.8/SCN10A). It is approximay 15-fold more potent on Nav1.7/SCN9A than on Nav1.5/SCN5A channels and acts on Cav3.1/CACNA1G and interacts more weakly with the related T-Type channel Cav3.2/CACNA1H but potently inhibits the L-type calcium channel Cav1.2/CACNA1C. ProTx-II also binds to phospholipids. ProTx-II, a selective inhibitor of Nav1.7 sodium channels, blocks action potential propagation in nociceptors.
Biotinyl-ProTx-II is a N-ter biotin labeled version of the wild-type ProTx-II useful for a wide range of experimentations.
Biotinyl-ProTx-II技術(shù)資料
氨基酸序列：
Biotin-Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Ser-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Met-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Leu-Trp-OH
二硫鍵：Cys2-Cys16, Cys9-Cys21 and Cys15-Cys25
長(zhǎng)度 (aa)： 30
分子式： C178H254N48O43S9
分子量：4052.74 Da
外觀： White lyophilized solid
可溶性： water and saline buffer
CAS 號(hào)：not available
來(lái)源：Synthetic
純度：> 88 %
產(chǎn)品信息
12PTB002-00100 | Biotinyl-ProTx II | 0.1mg |
12PTB002-00500 | Biotinyl-ProTx II | 0.5mg |
